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Neutrophilic eccrine hidradenitis (NEH) usually is a cutaneous complication of chemotherapy, but it can also occur for other reasons. It consists of fever and non specific skin lesions. It is rare, and self-limited.〔James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. ISBN 0-7216-2921-0. 〕〔Neutrophilic eccrine hidradenitis. Bachmeyer C, Aractingi S. Clin Dermatol. 2000 May-Jun;18(3):319-30.〕 ==Etiology== The overwhelming majority of neutrophilic eccrine hidradenitis (NEH) is seen in patients with cancer, especially leukaemia, who receive chemotherapy with a cytotoxic drug. These include: Bleomycin, chlorambucil, cyclophosphamide, cytarabine, doxorubicin, lomustine, mitoxantrone, topotecan, and vincristine.〔Mucocutaneous reactions to chemotherapy. Susser WS, Whitaker-Worth DL, Grant-Kels JM. J Am Acad Dermatol. 1999;40(3):367-98.〕 NEH was first described in 1982 in a patient with acute myeloid leukaemia (AML) who had received cytarabine as chemotherapy.〔Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy. Harrist TJ, Fine JD, Berman RS, Murphy GF, Mihm MC Jr. Arch Dermatol. 1982;118(4):263-6.〕 Cancer itself, infections, and other medicinal drugs also can lead to NEH. NEH has been reported in patients with cancer who have not received any form of chemotherapy (i.e., as a paraneoplastic syndrome), in patients with HIV and/or AIDS, and after the use of paracetamol (acetaminophen). Also the use of targeted agents can lead to NEH, e.g. imatinib, a tyrosine kinase inhibitor.〔Unusual manifestations of acute leukemia. Case 2. Leukemia and rash: paraneoplastic or drug-induced? Blank C, Wagner HM, Hohenleutner U, Andreesen R. J Clin Oncol. 2000 Oct 1;18(19):3437-9.〕〔Neutrophilic eccrine hidradenitis: a case report and review of the literature. Bailey DL, Barron D, Lucky AW. Pediatr Dermatol. 1989;6(1):33-8.〕〔 Neutrophilic eccrine hidradenitis: a case report and review of the literature. Margolis DJ, Gross PR. Cutis. 1991;48(3):198-200.〕〔Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. Scheinfeld N. J Drugs Dermatol. 2006 Mar;5(3):228-31.〕 NEH has also been described without any known reason (idiopathic cases), including idiopathic cases in children.〔 Generalized idiopathic neutrophilic eccrine hidradenitis in childhood. Lee WJ, Kim CH, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK. Int J Dermatol. 2010 Jan;49(1):75-8.〕〔Idiopathic palmoplantar eccrine hidradenitis in children. Ben-Amitai D, Hodak E, Landau M, Metzker A, Feinmesser M, David M. Eur J Pediatr. 2001 Mar;160(3):189-91.〕 The exact cause of NEH is unknown. In patients receiving chemotherapy, it has been postulated that a high concentration of the cytotoxic drug in sweat has a direct toxic effect on the eccrine glands.〔Neutrophilic eccrine hidradenitis: a distinctive rash associated with cytarabine therapy and acute leukemia. Flynn TC, Harrist TJ, Murphy GF, Loss RW, Moschella SL. J Am Acad Dermatol. 1984;11(4 Pt 1):584-90.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「neutrophilic eccrine hidradenitis」の詳細全文を読む スポンサード リンク
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